Cohesion Technologies, Inc.

Cohesion Corporation

Angiotech Pharmaceuticals, Inc.

Angiotech Biomaterials Corp.

David H Sierra

Frank A DeLustro

Donald G Wallace

Jeffrey J Prior

Stanley R Conston

Abigail Freeman

Alan S Michaels

Gerald G Fuller

The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compositions are used in a kit comprising two different components, one of which is autologous patient's plasma as the source of fibrinogen, and the other of which is the thrombin-containing composition which also contains microfibrillar collagen.

Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof

The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an inter-connecting network is formed. The resultant mechanically stable implant allows for tissue and fluid influx into the matrix. The invention is also directed to a method for repair of mammalian tissue using the above-described implant.

Collagen-polymer matrices with differential biodegradability

The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred embodiment of the present invention, the compositions are used in a kit comprising two different components, one of which is autologous patient's plasma as the source of fibrinogen, and the other of which is the thrombin-containing composition which also contains microfibrillar collagen having an average diameter of about 3-30 nanometers.

Compositions containing thrombin and microfibrillar nanometer collagen,

A fluid separation device and in-line orifice mixer system is disclosed. The fluid separation device utilizes a syringe, which is used for obtaining a fluid sample such as blood, in a centrifugation device, and further utilizes the syringe as a source of a separated fluid portion for storage and transfer for subsequent applications. The syringe containing the separated portion source and a second syringe containing a second source are connected to the in-line orifice mixer device. The mixer device comprises a plurality of orifice walls each providing an orifice non-aligned with adjacent orifices to homogeneously mix the plurality of components. The mixer device may further comprise an exit orifice wall with one or more orifices for discharge of the homogeneous mixture.

Cell separation device and in-line orifice mixer system

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Atherton, CA, United States of America

David H Sierra