Portland State University

Designmedix, Inc.

David H Peyton

Steven P Burgess

Katherine M Liebman

Bornface Gunsaru

This disclosure provides a new class of compounds referred to as 'reversed chloroquines' (RCQs), which are highly effective against CQand CQmalaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQreversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQor CQsp. (such as).

Quinoline derivatives and uses thereof

The disclosure provides modified chloroquine compounds having single ring or fused ring moieties. Also provided are pharmaceutical compositions comprising such compounds, methods of using such compounds to inhibit or treat diseases or conditions caused by chloroquine-resistant (CQ) and chloroquine-sensitive (Cq) malaria parasites and other CQ-susceptible microorganisms, and processes and intermediates useful for preparing such compounds.

Growing community of inventors

Portland, OR, United States of America

David H Peyton