Affymetrix, Inc.

Eos Biotechnology, Inc.

Protein Design Labs, Inc.

Pdl Biopharma, Inc.

Other

Leland Stanford Junior University

Princeton University

Cedars-sinai Medical Center

Abbott Biotherapeutics Corp.

David H Mack

Kurt C Gish

Keith E Wilson

Mark S Chee

Lubert Stryer

Thomas R Gingeras

Anthony J Berno

Ghassan Ghandour

Ching Wang

Maureen Elizabeth Murphy

David J Lockhart

Daniel E H Afar

David J Balaban

Arnold J Levine

David B Agus

Josie Dai

Elina Khurgin

Michael Mittman

Richard Glynne

Jim Snyder

Arnold L Levine

Edward Yat Wah Tom

Edward Yat Tom

Chris Goodnow

Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Compositions against cancer antigen LIV-1 and uses thereof

Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein are methods that can be used to identify modulators of prostate cancer.

Methods of diagnosis of androgen-dependent prostate cancer, prostate cancer undergoing androgen withdrawal, and androgen-independent prostate cancer

Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.

Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer

This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on therpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.

Chip-based speciation and phenotypic characterization of microorganisms

This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on thegene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.

Chip-based species identification and phenotypic characterization of microorganisms

The invention provides for the identification of all genes, whether known or novel, which are differentially expressed within and among B cells, making possible the characterization of their temporal regulation and function in the B cell response and/or in B cell mediated disorders. Expression profiles, nucleic acids and proteins are provided for differing states of B cells, including resting, naive, activated, tolerant and immunosuppressed B cells. The present invention makes possible the identification and characterization of targets useful in prognosis, diagnosis, monitoring, rational drug design, and/or therapeutic intervention of immune system disorders.

Methods of screening for B cell activity modulators

The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of murine genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. As such, the invention related to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics.

Methods of genetic analysis using nucleic acid arrays

Described herein are methods that can be used for diagnosis and prognosis of breast cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate breast cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in breast cancer are described.

Methods of diagnosing breast cancer

Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.

Methods of diagnosing of colorectal cancer, compositions, and methods of screening for colorectal cancer modulators

Methods for detection and diagnosing of breast cancer

This invention provides methods, compositions and apparatus for mapping the regulatory relationship among genes by massive parallel monitoring gene expression. In some embodiments, mutations in the up-stream regulatory genes are detected by monitoring the change in down-stream gene expression. Similarly, the function of a specific mutation in a up-stream gene is determined by monitoring the down-stream gene expression. In addition, regulatory function of a target gene can be determined by monitoring the expression of a large number of down-stream genes. The invention also provides specific embodiments for detecting p53 functional homozygous and heterozygous mutations and for determining the function of p53 mutations.

Expression monitoring for gene function identification

Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal cancer are described.

Methods of diagnosing and determining prognosis of colorectal cancer

Methods of diagnosing breast cancer, compositions, and methods of screening for breast cancer modulators

Growing community of inventors

Menlo Park, CA, United States of America

David H Mack