University of British Columbia

Other

Qlt Phototherapeutics, Inc.

Abbott Laboratories Corporation

Sandoz Gmbh

Qlt, Inc. and

Qlt Phototherapeutices Inc.

Qlt Inc.

David H Dolphin

Ethan D Sternberg

Julia G Levy

Tilak P Wijesekera

Anna M Richter

Ross W Boyle

Christian Bruckner

Ashok Jain

Ronald Erwin Boch

Elizabeth M Waterfield

Lily Y Xie

Andrew Norman Tovey

Jill Kirsten MacAlpine

Jack K Chow

Rubinah K Chowdhary

Hang Tang

Jack J Chow

Roberta L Farrell

David W C Hunt

David W Hunt

Thomas K Kirk

Carl E Van Winckel

Theodore E Maione

Kent F Van Winckel

Elena Dumitrescu

Claire K Johnson

Taku Nakano

Xuejun Peng

Paul Y Hin

Rubinah Kausar Chowdhary

Ethan Sternberg

David R Hill

Elaine C Lee

Johannes E Van Lier

Svetlana V Kudrevich

Mukund S Chorghade

Jacques Rousseau

Svetlana V Selivanova

Fumio Hino

Christian Brückner

Angela M Desjardins

David Wc Hunt

Jain Ashok

Andrew N Tovey

The invention is generally related to the field of photodynamic therapy by use of photosensitizers and stabilized formulations of the photosensitizers. These formulations may be used to deliver a photosensitizer as a pharmaceutical, agricultural, or industrial agent. The photosensitizer containing formulations and compositions of the invention comprise one or more block copolymers. Furthermore, the invention relates to processes for the production of, and application of, said formulations and compositions as photosensitizer drug delivery systems.

Drug delivery systems for photodynamic therapy

The invention is generally related to the field of formulating medicaments in association with a solid support. Such formulations comprising photosensitizers, and their use in photodynamic therapy, are also provided. Methods for the production of the medicament formulations are also disclosed.

Supports for photosensitizer formulations

New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomersand the metallated and/or labeled and/or conjugated forms thereof

Ethylene glycol esters as photoactive agents

Improved &#x3b2;,&#x3b2;'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compounds are provided as photosensitizers. Pharmaceutical compositions and photodynamic therapy comprising them are also disclosed.

&#x3b2;,&#x3b2;'-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins

The present invention discloses novel photoactive compounds that may be crosslinked to target substrates. Methods for the preparation and use of the compounds, as well as compositions comprising them, are also disclosed.

Methods and compositions for photo-cross linking photoactive compounds to target tissue

A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of detection are 2.06&#xd7;10M, and the relative standard deviation for the separation was 2.90% to 4.64%. The BPD enantiomers can be quantitatively determined in the range of 10to 10mg mL. In comparison with HPLC, CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.

Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis

Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition is described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.

1,3-dipolar cycloadditions to polypyrrolic macrocycles

Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition are described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.

1,3-Dipolar cycloadditions to polypyrrolic macrocycles

Novel 2-pyrrolylthione derived metal chelate compounds are disclosed as imaging and therapeutic agents. Compositions and methods for their preparation and use as diagnostic imaging and therapeutic agents are also disclosed.

Radiometal complexes of 2-pyrrolylthiones and their use as radiopharmaceuticals for imaging and therapy

A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of detection are 2.06&times;10,M, and the relative standard deviation for the separation was 2.90% to 4.64%. The BPD enantiomers can be quantitatively determined in the range of 10,to 10,mg mL,. In comparison with HPLC, CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.

New compounds useful in photodynamic therapy are of the formula ##STR1## and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof

The present invention provides for novel therapeutic macrocycle compounds useful in photodynamic therapy that are based on the chlorin ring system. The macrocycle compounds have, in many cases, wavelengths of activation at about 670 nm, characteristics of chlorins, and are stabilized against oxidation by the attachment to the chlorin ring of a structure that comprises one or more exocyclic rings that contribute at least one nitrogen atom. Protonation or covalent modification of this nitrogen atom, or other covalent modification of the one or more exocyclic rings permits optimization of pharmacalogically relevant properties including, for example, solubility. Representative chlorins include the pyridochlorins depicted as follows ##STR1##

Synthesis of long wavelength absorbing photosensitizers

The invention provides for tripyrrane compounds of the formula ##STR1## wherein: each Q represents, typically, an alkyl group, cycloalkyl group, aryl group, or a heteroaryl group; and each R represents hydrogen, an alkyl group, alcohol group, or a carbonyl-containing group. Additionally, there are described methods to prepare such compounds, for example, comprising the steps of:

Meso-substituted tripyrrane compounds, compositions, and methods for

Growing community of inventors

Vancouver, Canada

David H Dolphin