Icos Corporation

David H Chantry

Merl F Hoekstra

Patrick W Gray

Douglas A Holtzman

Michael C Deeley

Ronald Godiska

Carol J Raport

The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C&#x2014;C chemokine designated 'Macrophage Derived Chemokine' (MDC), and polypeptide fragments and analogs thereof. Also provided are materials and methods for the recombinant or synthetic production of the chemokine, fragments, and analogs; and purified and isolated chemokine protein, and polypeptide fragments and analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing. Also provided are assays for identifying modulators of MDC chemokine activity.

Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein, and polypeptide analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing.

Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same

The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the like.

Lipid kinase

The present invention provides purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6. Also provided by the invention are methods and materials for the recombinant production of GRK6 enzyme and methods for identifying compounds which modulate the protein kinase activity of GRK6.

Growing community of inventors

Seattle, WA, United States of America

David H Chantry