Eli Lilly and Company

David H Berg

Marvin M Hoehn

Robert L Hamill

LaVerne D Boeck

Antibiotic A-32724 complex, comprising microbiologically-active, related factors A, B and C, is produced by submerged, aerobic fermentation of a strain of Chaetomella raphigera Swift NRRL 12331. The A-32724 antibiotics are closely related antibiotics. The individual A-32724 factors are separated by chromatography. In addition to their antibacterial activity, the A-32724 factors inhibit certain enzymes and exhibit antihypertensive properties.

A-32724 Antibiotics and process for production thereof

Antibiotic A-28086 complex, comprising microbiologically active, structurally related factors A, B, and D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 5758. Individual factors A, B, and D are separated and isolated by chromatography. The A-28086 antibiotics are antibacterial, antifungal, antiviral, anti-PPLO, anticoccidial, insecticidal and acaricidal agents and also increase feed-utilization efficiency in ruminants.

Method of increasing feed utilization

Antibiotic A-28086 and process for production thereof

Recovery of an antibiotic selected from the group consisting of antibiotic A-28086 factor A, antibiotic A-28086 factor B, antibiotic A-28086 factor D, and salinomycin by acidifying the fermentation broth in which said antibiotic is produced to about pH 2.0-4.0 and separating the antibiotic with the culture solids.

Antibiotic A-28086 recovery process

Antibiotic A-30641, a new epidithiodiketopiperazine antifungal agent, is produced together with canadensolide in the A-30641 antibiotic complex by submerged aerobic fermentation of Aspergillus tamarii NRRL 8101.

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Greenfield, IN, United States of America

David H Berg