Incyte Pharmaceuticals, Inc.

Incyte Genomics, Inc.

Incyte Corporation

Sri International

David Gray Streeter

Surya K Goli

Jennifer L Hillman

Douglas A Fisher

Douglas H Gooding

Neil C Corley

Olga Bandman

Purvi Shah

Mary Faris

Paul H Johnson

Jeanne F Loring

Jerome B Lazar

Debora W Tingley

Samuel T Labrie

Carla M Edwards

The invention provides a human cyclic GMP phosphodiesterase (PDE9A) and polynucleotides which identify and encode PDE9A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE9A.

Cyclic GMP phosphodiesterase

The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Tumor-associated antigen

The present invention relates to a combination comprising a plurality of polynucleotide probes that are modulated in response to EGF and which are associated with breast cancer, and which may be used in their entirety or in part as to diagnose, to stage, to treat, or to monitor the treatment of a subject with a breast cancer.

Detection of genes regulated by EGF in breast cancer

The invention provides a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the mammalian nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule.

Down syndrome critical region 1-like proteins

The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCBS. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.

Human cytochrome b5

The invention provides a human rSec6 related vesicle transport protein (HSEC6) and polynucleotides which identify and encode HSEC6. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSEC6.

DNA encoding human RSEC6 related protein

The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.

Regulator of gene transcription

The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCB5. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.

Human cytochrome B5

Regulation of gene transcription

Human laminin B.sub.1 peptides have been produced. The invention provides novel peptides which contain substantial amino acid sequence similarity to amino acids 897 to 936 in the human sequence. These peptides have been found to have enhanced antimetastatic activity.

Growing community of inventors

Boulder Creek, CA, United States of America

David Gray Streeter