The University of British Columbia

Radical Therapeutix

David Granville

Bruce McManus

Rani Cruz

Ciara Chamberlain

Wendy Boivin

Mark J Yeager

Eric F Johnson

Paul Wentworth

Roberta Gottlieb

Wendy Bolvin

A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin.

Granzyme A and granzyme B diagnostics

A method of medical treatment or prevention of a vasculopathy, comprising administering a therapeutically effective amount of a granzyme B inhibitor to a subject in need thereof is provided. In other aspects uses of Granzyme B inhibitors for treatment or for preparation of medicaments for treatment of a vasculopathy are provided.

Treatment of dissection, aneurysm, and atherosclerosis using granzyme B inhibitors

Methods of treating or inhibiting ischemia and reperfusion injury are provided.

Method to inhibit ischemia and reperfusion injury

Growing community of inventors

Coquitlam, Canada

David Granville