Smithkline Beecham Corporation

Other

Global Invacom Limited

David Glynn Smith

Derek R Buckle

Robert William Ward

David Haigh

John Liddle

Jason Witherington

Henry Anderson Kelly

Martin Pass

Stephen Garland

Deidre Mary Bernadette Hickey

Robert John Ife

Edmund F Petruzzelli

Stuart Bailey

Andrew Faller

Ruth Judik Mayer

Gary Stafford

Alastair David Reith

Ashley Edward Fenwick

Julie Caroline Holder

Gary Christie

Ariane Elizabeth Marolewski

Ashley E Fenwick

Matthew Paul Coghlan

The invention relates to apparatus and method which can be used to receive broadcast digital data. The apparatus and method are provided at one or more receiving locations and is connected to one or more broadcast data receivers at each location. The apparatus is capable of receiving and processing data in linear and/or circular polarity formats and the operating condition of the same can be altered in response to a command signal broadcast to the receiving locations prior to the transmission of data in a new format such as to the change in the operating condition of the apparatus to receive and process linear as well as the previously broadcast circular polarity format data.

Apparatus for selected provision of linear and/or circular polarity signals

The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclcyl and the alkyl moieties may each inedepently be unsubstituted or substituted; and Ris unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention inlcudes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.

Pyrazolopyridines and pyrazolopyridazines as antidiabetics

The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclyl and the alkyl moieties may each independently be unsubstituted or substituted; and Ris unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention includes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.

Method and compounds

Benzamide derivatives as thrombin inhibitors

Inhibitors of the Production of s-CD23 and the secretion of TNF are provided.

Inhibitors of the production of S-CD23 and the secretion of TNF

The present invention is to the discovery of a novel CD23 processing enzyme which is of importance in the human immune response and regulation of IgE production, and is a protein expressed on the surface of a variety of cells.

CD23 processing enzyme preparation

##STR1## A compound of formula (I) or, if appropriate, a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 each independently represent an alkyl group or a moiety of formula (a): --(CH.sub.2).sub.m --A, wherein m represents zero or an integer 1, 2 or 3 and A represents a substituted or unsubstituted cyclic hydrocarbon radical; R.sup.3 represents hydrogen, NO.sub.2 or a halogen atom, an alkoxy group or a group of formula NR.sup.s R.sup.t wherein R.sup.s and R.sup.t each independently represent hydrogen or alkyl or R.sup.s and R.sup.t together with the nitrogen to which they are attached form a phthalimido group, the phthalimido group being substituted or unsubstituted in the phenylene moiety or R.sup.3 represents a moiety of formula (b), wherein R.sup.5 represents substituted or unsubstituted alkyl or a substituted or unsubstituted aryl group; and R.sup.6 represents hydrogen or a group SO.sub.2 R.sup.7 wherein R.sup.7 represents substituted or unsubstituted alkyl, a substituted or unsubstituted aryl group; R.sup.4 represents SO.sub.2 R.sup.8, wherein R.sup. 8 represents substituted or unsubstituted alkyl or a substituted or unsubstituted aryl group, or, when R.sup.3 represents a moiety of the above-defined formula (b), then R.sup.4 represents hydrogen or a substituted or unsubstituted alkyl group or a benzyl group substituted or unsubstituted in the phenyl ring a process for preparing such a compound, a composition comprising such a compound and the use of such a compound and composition in medicine.

Xanthine derivatives

Growing community of inventors

Harlow, United Kingdom

David Glynn Smith