Syntex (u.s.a.) Inc.

David George Putman

Lee Allen Flippin

Robert J Greenhouse

Shu-Hai Zhao

Jacob Berger

Saul Jaime-Figueroa

Aubry Kern Miller

Klaus Kurt Weinhardt

Yanzhou Liu

Robin D Clark

Colin C Beard

Ralph New Harris, Iii

Lawrence Emerson Fisher

David Bruce Repke

Indole derivatives with 5HT6 receptor affinity

The aryl pyrimidine derivatives and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, including utility as selective 5HT.sub.2B -antagonists. The 5-HT.sub.2B antagonist is a compound of the formula: ##STR1## wherein: R.sup.1 is hydrogen, alkyl, lower alkoxy, hydroxyalkyl, cycloalkyl, cycloalkyl lower alkyl, alkenyl, lower thioalkoxy, halo, fluoroalkyl, --NR.sup.6 R.sup.7, --CO.sub.2 R.sup.8, --O(CH.sub.2).sub.n R.sup.9, or lower alkyl optionally substituted with hydroxy, alkoxy, halo, or aryl; in which

Aryl pyrimidine derivatives and uses thereof

The aryl pyrimidine derivatives and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, including utility as selective 5HT.sub.2B -antagonists.

Aryl pyrimidine derivatives

The disclosed pyrimidine derivatives, and pharmaceutically acceptable salts and N-oxides thereof, exhibit useful pharmacological properties, in particular use as selective 5HT.sub.2B -antagonists. The invention is also directed to formulations and methods for treatment.

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Saratoga, CA, United States of America

David George Putman