Other

Emory University

Virginia Tech Intellectual Properties, Inc.

Binghamton University

David George Ian Kingston

John F Kadow

Thota Ganesh

Mahendra Devichand Chordia

Prakash G Jagtap

Ami S Lakdawala

Susan Lynn Bane

James Patrick Synder

Constrained paclitaxel derivatives include a bridge extending from the C-3' phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.

Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents

2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity. Further, the compound, analogs and intermediates may be used to treat cancer when applied in an effective amount by means such as a pharmaceutical composition.

2-aroyl-4-acyl paclitaxel (Taxol) analogs

Growing community of inventors

Blacksburg, VA, United States of America

David George Ian Kingston