Third Pole, Inc.

David G Zapol

Gregory Walter Hall

Wolfgang Scholz

Benjamin Apollonio

Frank J Heirtzler

Andrew Ferencz

Ian J Gillerman

Frank Heirtzler

Gregory W Hall

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Systems and methods for ambulatory generation of nitric oxide

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NOgas analysis sensors without the use of a calibration gas.

Systems and methods for generating nitric oxide

System and methods for ambulatory generation of nitric oxide

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San Francisco, CA, United States of America

David G Zapol