The University of New Mexico

University of Florida Research Foundation Inc

University of California

Other

Qtl Biosystems, LLC

David G Whitten

Kirk S Schanze

Thomas S Corbitt

Anand Parthasarathy

Eric H Hill

Eunkyung Ji

Motokatsu Ogawa

Linnea K Ista

Dimitri Dascier

Duncan W McBranch

Ying Wang

Harry Craig Pappas

Liaohai Chen

Gabriel P Lopez

Hsing-Lin Wang

Kirsten Nicole Cicotte

Elizabeth LeBleu Dirk

Patrick L Donabedian

Kiran Bhaskar

Robert Michael Jones

Yun Huang

Dylan Brown

Jianzhong Yang

Jonathan Robert Sommer

Edward Strach

Mohammed Khalil

Xuzhi Zhu

Yanli Tang

Zhijun Zhou

Arjun Thapa

Yue Zhang

Eva Yung Hua Chi

Aaron Neumann

Frauke Rininsland

Jonathan P Hulse

Su Xu

Sireesha Chemburu

David Keller

Matthew Graus

Rina Sylejmani

Subhadip Goswami

Adeline Fanni

Matthew Creyer

Florencia A Monge

Eva Y Chi

Troy S Bergstedt

Rong Wang

Wensheng Xia

Kevin Ley

Liangde Lu

Sriram Kumaraswamy

Ramanathan Nagarajan

Brett Andrzejewski

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethylylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

P-phenylene ethynylene compounds as bioactive and detection agents

The present disclosure provides an antimicrobial substrate including a substrate and a polythiophene polymer. The polythiophene polymer has a number of repeated monomer units from n is 5-14 or 30 to 120, a number average molecular weight (Mn) from 1,000 to 4,000 or 10,000 to 40,000; and a polydispersity index (PDI) from 1 to 1.3. The present disclosure also provides the polythiophene polymer and uses thereof.

Substituted thiophene oligomers and polymers

Novel agents and theranostics for use as controllable and selective photosensitizers for the diagnosis, treatment and/or tracking of amyloid protein aggregates and amyloid diseases.

Theranostics for protein misfolding diseases

Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a &#x3b2;-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the &#x3b2;-glucan to increase immunogenicity of the fungus.

Treatment and prevention of fungal infections

The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R-Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R-Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Conjugated polyelectrolytes and methods of using the same

Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.

The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

Structure, synthesis, and applications for oligo phenylene ethynylenes (OPEs)

The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

Antimicrobial materials and methods

The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.

Charged singlet-oxygen sensitizers and oppositely-charged surfactants

Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure &#x2014;R&#x2014;Y&#x2014;R&#x2014;Z&#x2014;. At each occurrence, Ris independently chosen from 1,4-bonded phenylene substituted by &#x2014;X&#x2014;R&#x2014;Rj times and 2,5-bonded thiophene substituted by &#x2014;X&#x2014;R&#x2014;Rj times. At each occurrence, Y is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. At each occurrence, Ris independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and &#x2014;C&#x2261;C&#x2014;. The variables j, R, and Rare as defined herein.

Growing community of inventors

Albuquerque, NM, United States of America

David G Whitten