Duke University

David G Ousterout

Charles A Gersbach

Joshua B Black

Isaac B Hilton

Pablo Perez-Pinera

Pratiksha I Thakore

Ami M Kabadi

Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.

Genetic correction of mutated genes

Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.

RNA-guided gene editing and gene regulation

Growing community of inventors

Raleigh, NC, United States of America

David G Ousterout