Miles Inc.

Bayer Pharmaceuticals Corporation

David G Osterman

Michael E Katz

Richard D Connell

Robert D Dally

Rudolf H Hanko

James A Landro

Walter Pickett

Stephan Schneider

The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes, diabetes-related disorders, obesity, cardiovascular disease, cancer, and other diseases or disorders, using this phase partition system.

Method for assaying enzyme activity

A class of compounds that suppress human T-lymphocyte proliferation is disclosed. The active compounds essentially contain at least the following structure: ##STR1##

2-oxoethyl derivatives as immunosuppressants

Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1##

Aminomethylene derivaties as immunosuppressants

Sulfonamide aminomethylene derivatives as immunosuppressants

Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, n, X.sup.1 and Z are defined in the specification.

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Glastonbury, CT, United States of America

David G Osterman