Nantbio, Inc.

Nantbioscience, Inc.

Hememics Biotechnologies, Inc.

Cellphire, Inc.

Athos Therapeutics, Inc.

Cellphirc, Inc

The Scripps Research Institute

The Rockefeller University

Imaginab, Inc.

David G Ho

Chunlin Tao

Qinwei Wang

Laxman Nallan

Tulay Polat

Patrick Soon-Shiong

Neil P Desai

Stephen P Bruttig

Paul Weingarten

Cindy S Orser

Xiaowen Sun

Alan Rudolph

Chi-Huey Wong

Moriya Tsuji

Keith Andrew Moskowitz

Dimitrios Iliopoulos

Masakazu Fujio

Forrest Arp

Anna B Juncker-Jensen

Dimitra Chalkia

Arye Lipman

Joshua Dee

Heather Jones

Iordanis Karagiannidis

Phithi Nguyen

Alan S Rudolph

Tove Olafson

Doug Wu

Disclosed herein are quinazolinyl compounds, compositions, and methods of use thereof. The compounds may be used in the treatment of autoimmune disorders or cancer.

Small molecules for the treatment of autoimmune diseases and cancer

The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.

Pyrimidine derivatives as kinase inhibitors and their therapeutical applications

Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Compositions and methods of targeting mutant K-ras

The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.

Substituted indol-5-ol derivatives and their therapeutic applications

Substituted indol-5-ol derivatives and their therapeutical applications

The present invention provides compositions (i.e., preservation solutions) for preserving biologies comprising at least one membrane penetrable sugar, at least one membrane impenetrable sugar, at least one anti-microbial agent, at least one anti-oxidant, adenosine, albumin, a salt, a buffer, and a chelating agent, and to methods of using such preservation solutions to preserve biologies.

Preservation solutions for biologics and methods related thereto

The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of preparing the same, and to methods of treating animals using the same.

Desiccated biologics and methods of preparing the same

The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Benzyl substituted triazine derivatives and their therapeutical applications

The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.

Triazine derivatives and their therapeutical applications

The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, methods of using the platelets for therapeutic, diagnostic, and research purposes, and kits comprising the freeze-dried platelets.

Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use

The present invention provides freeze-dried platelets and compositions comprising freeze-dried platelets for use as a diagnostic and calibration reagent for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of the invention are also included.

Freeze-dried platelets, method of making and method of use as a diagnostic agent

The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a hemostat, such as for treating bleeding or injuries associated with bleeding. It also provides methods of treating injuries or wounds, and methods of causing blood to clot. Likewise, it provides methods of promoting healing of wounds or of healing wounds.

Use of stabilized platelets as hemostatic agent

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Monterey Park, CA, United States of America

David G Ho