Victoria Link Limited

Health Innovation Ventures B.v.

Leland Stanford Junior University

Auckland Uniservices Limited

Convert Pharmaceuticals Sa

David Francis Ackerley

Jeffrey Bruce Smaill

Adam Vorn Patterson

Amir Ashoorzadeh

Christopher Paul Guise

Janine Naomi Copp

Alexandra Marie Mowday

Elsie May Williams

A C Matin

Katherine Jane Robins

Yoram Barak

Alistair Sinclair Brown

Christopher H Contag

Jianghong Rao

Stephen Howard Thorne

Jack Urquhart Flanagan

Susan V Lynch

Gareth Adrian Prosser

Sophie Phillipa Syddall

Method for the detection of glutamine and its analogues are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogues, including diagnostic methods. Further provided are methods that utilise glutamine analogues for the synthesis of coloured pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.

Methods of detecting and measuring glutamine and analogues thereof, and methods related thereto

The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: more particularly, although not exclusively, the enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.

Bacterial nitroreductase enzymes and methods relating thereto

The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.

Prodrugs and methods of use thereof

Method for the detection of glutamine and its analogs are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogs, including diagnostic methods. Further provided are methods that utilize glutamine analogs for the synthesis of colored pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.

Compositions and methods are provided for bioremediation of toxic metals.

Nitroreductase enzymes for bioremediation

Compositions and methods are provided for the treatment of cancer.

Nitroreductase enzymes

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Wellington, New Zealand

David Francis Ackerley