Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines S.e.c.

Societe De Commercialisation Des Produits De La Recheche Appliquee-socpra-science Sante Et Humaines S.e.c.

Socpra Sciences Sante Et Humaines S.e.c.

David Fortin

Fernand Gobeil

Witold A Neugebauer

Brigitte Guerin

Domenico Regoli

Robert Sabbagh

Martin Lepage

It is provided new chemical entities allowing simultaneous diagnosis and treatment of cancers. More specifically, it is provided a theranostic compound consisting of a stabilized peptide ligand (agonists and antagonists) for the kinin B1 receptors (B1R) conjugated to specific radionuclides (e.g.Cu) suitable for dual imaging/radiotherapy applications.

Kinin-based theranostic probes for solid cancers and uses thereof

The present invention provides for novel kinin B1 receptors peptide agonists of formula (I) having very good to excellent affinities and selectivity for the Breceptor, in vitro and in vivo increased resistance to enzymatic degradation, superior pharmacokinetic properties to those of naturally occurring agents, capacity to significantly enhance delivery of chemotherapeutic substances across the blood brain barrier and within peripheral tissues for the treatment of tumors, capacity to protect and restore kidney, heart, brain and other organ functions, when given alone or in combination with other therapies in the treatment of hypertension, diabetes and other cardiovascular diseases particularly, but not limited to, atherosclerosis and arteriosclerosis. Formula (I): aa-aa-aa-aa-aa-aa-aa-aa-Ser-Pro-D-Phe-X.

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Sherbrooke, Canada

David Fortin