U.S. Nutraceuticals, LLC

Other

University of Alberta

Tonix Pharma Limited

David Evans

W Stephen Hill

Ryan Noyce

Don B Gammon

Seth Lederman

The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Synthetic chimeric poxviruses

The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy. Also provided in the disclosure are vector constructs for generating mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides poxviruses comprising a functionally inactivated R2 gene.

Oncolytic viruses and methods for treating neoplastic disorders

The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.

A human or animal dietary supplement composition comprising one or more long chain (C24-C36) primary alcohols (policosanols) dispersed in food-grade oils or fats where the policosanol particle size is substantially less than ten (10) microns. The composition (Nanocosanol&#x2122;) is effective and convenient for supporting blood lipid health.

Dietary supplement composition for blood lipid health

A method for enhancing gastrointestinal motility in humans and other mammals comprises administering a therapeutically effective amount of a composition having one or more long chain (C24-C36) primary alcohols as policosanols dispersed in one or more food-grade fats or oils, wherein the particle sizes of the alcohols are substantially less than 10 microns.

This invention relates to face masks, and particularly respiratory face masks for administering a gas, such as oxygen or a mixture thereof, to a patient, and specifically when an operation is performed involving a local anaesthetic or when a patient is recuperating in an intensive care unit or post-anaesthetic care unit. The face mask includes a body adapted to cover at least the nose of a wearer, and having a peripheral edge for substantially sealing at least a portion of the body of the mask to the face of a wearer. Moreover, the peripheral edge is contoured to extend over the bridge of the nose and well below the level of the eyes of the patient or wearer. The face mask includes an inlet for directing a flow of gas to the interior of the mask, and a port for allowing the exhaled air stream by the patient to flow therethrough, and particularly to a tube for directing such flow to suitable monitoring apparatus for measuring the components thereof, such as a mass spectrometer or capnograph. The port includes a connector having a configuration for releasably engaging one end of the tube presented thereto, with such connector including a conduit, and, in the preferred embodiment, in the term of a tubular portion or element, for directing the flow of gas from the interior of the mask to such tube.

Face mask with gas sampling port

The invention provides a catheter placement apparatus for use in inserting a catheter to a preferred depth, the device comprising a surgical needle with a longitudinal window through which a catheter inserted into the needle can be viewed, and a catheter having a colored patch of the same length as the window and a series of spaced, visually distinct markings, proximal to the patch. The position of the catheter can be accurately located by aligning the colored patch with the window and then inserting the catheter until at least one mark appears in the window, recording the distance of a mark from the surface of the skin and using this recorded distance to relocate the catheter, if necessary.

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Edmonton, Canada

David Evans