Illumina Corporation

Illumina Singapore Pte. Ltd.

Accumetrics, Inc.

Helixis, Inc.

David Elliott Kaplan

Ashish Kumar

Anthony John De Ruyter

Richard Alan Kelley

Lea Kobeli

Edward Wilson Licitra

James Michael Osmus

Bradley Kent Drews

Laurence Warden

John M Beierle

Beng Keong Ang

Heng Kuang Cheng

Andrew J Zoolakis

Adrian Fawcett

Max Warren Pollock

Robert Nicholas Dean

Kevin Daley Simmons

Richard L Lemoine

Raymond Lawrence Oyung

Judy Macemon

Richard Lemoine

Flow cell cartridge

Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Flow cell assemblies and related systems

A cartridge for use with chemical or biological analysis systems, as well as methods of using the same, is provided. The cartridge may include a floating microfluidic plate that is held in the cartridge using one or more floating support brackets that incorporate gaskets that may seal against fluidic ports on the microfluidic plate. The floating support brackets may include indexing features that may align the microfluidic plate with the seals.

Flowcell cartridge with floating bracket

Flowcell cartridge with floating seal bracket

A cartridge for use with chemical or biological analysis systems is provided. The cartridge may include a floating microfluidic plate that is held in the cartridge using one or more floating support brackets that incorporate gaskets that may seal against fluidic ports on the microfluidic plate. The floating support brackets may include indexing features that may align the microfluidic plate with the seals.

Flowcell cartridge

Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.

Detection apparatus having a microfluorometer, a fluidic system, and a flow cell latch clamp module

Full flowcell cartridge

Growing community of inventors

Carlsbad, CA, United States of America

David Elliott Kaplan