Rarecyte, Inc.

Microsoft Technology Licensing, LLC

Google Inc.

Applied Precision, Inc.

David Edward Stewart

Steve Quarre

Daniel E Campton

Joshua Nordberg

Ronald C Seubert

Lance U'Ren

Jonathan Lundt

Edward Shafer

Joel Smith

Jennifer Chow

Kirt A Debique

Nosakhare D Omoigui

Gabriel S DeBacker

Orry Wijanarko Soegiono

Jeffrey Jon Weir

Colin Ray Anthony

Jack A Roth

Zeke Koch

Pankaj Oberoi

Giampiero M Sierra

Paul Carlyle Goodwin

Garrett R Vargas

Matthew James Bolohan

William Scott Stauber

Jeremy Cooper

Steven Andrew Cover

Steven A Reese

William Michael Dougherty

David Citron

David Zearing

Nathan Bullock

Ben Constable

Martin E Van Tilburg

Joseph Manimala

Maria I Nunez

Shaoyu Yan

Charles Lu

Jonathan Erik Lundt

Steven Quarre

Jeremy Ryan Cooper

Daniel Campton

James Wilbur

Gisbert Spieles

Keith Mcclary

Ignatio Wistuba

Lance U'ren

Disclosed are apparatus and methods for securely holding a substrate in a repeatable and predictable manner regardless of substrate inconsistencies or deformities. In particular, described are apparatus and methods for consistently, repeatedly, predictably and securely holding a microscope slide on or within an imaging device. The apparatus may include a holder having securing blocks for securely holding a microscope slide that can be adjusted to account for warpage or deformations that may occur in the microscope slide.

Holding a substrate within a secondary device

Disclosed are optical trains for imaging systems. More particularly described are imaging systems configured to limit optical aberrations. Also disclosed are methods of limiting optical aberrations in imaging systems.

Optical trains for imaging systems and spectral edge detection

This disclosure is directed to a system and method for changing an angle of incidence of a filter or filter wheel.

Device, system, and method for changing angle of incidence of a filter or filter wheel

This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.

Automated substrate loading

This disclosure is directed to an apparatus for securely holding a substrate, such as a microscope slide. A holder includes a frame including at least three walls, such as a base, a first arm, and a second arm. Each wall includes a platform or a portion of a platform to support the substrate. The first arm includes at least one securing block and a second arm opposite the first arm includes a secure bar with a securing block. The securing blocks include a ramp to guide the substrate off of the platforms and a stopper to set a maximum lift distance and to constrain the substrate.

Apparatus for holding a substrate within a secondary device

This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. An enrichment agent may be added to a vessel that contains the sample for positive selection, or, in other words, to select or aid in selecting the target material from amongst the remainder of the sample. The enrichment agent may be, for example, immunomagnetic beads, buoyant beads, high-density beads, chemicals to change the density of the target material, or the like.

Apparatus, system and method for collecting a target material

This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate.

Apparatus for spreading a fluid across a substrate and method of using the same

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a displacement fluid, a collector, and a primary vessel. In another implementation, the system includes a processing vessel, a displacement fluid, a collector, and a primary vessel.

Apparatus, system, and method for collecting a target material

This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A first depletion agent may be added to a vessel that contains the sample to change the density of a non-target material.

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a primary vessel, such as a tube, a collector, and a two-part seal including an internal pliant part and an external constricting part. The internal pliant part may be a float and the external constricting part may be a sealing ring. The system may also include a processing vessel, such as an Eppendorf tube, a syringe or a test tube. The collector is sized and shaped to fit into a primary vessel and funnels the target material from the suspension through a cannula and into the processing vessel. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector.

This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A density-altering agent may be added to a vessel that contains the sample to change the density of a non-target material.

Growing community of inventors

Seattle, WA, United States of America

David Edward Stewart