Dow Global Technolgoies LLC

The Dow Chemical Company

David E Wallick

Robert L Sammler

Charles D Gartner

Puspendu Deo

George A Paul

Kalakota S Reddy

Yongfu Li

Warren L Treptow

John K Swayze

Kathryn Brown

Billy R Hardas

Meinolf Brackhagen

Oliver Petermann

Roland Adden

Attila G Relenyi

David M Meunier

Timothy J Gallagher

Roja Ergun

Connie I Deford

Connie L Deford

Bradley S Thomson

Jill D Streit

A process for preparing an aqueous solution of a methylcellulose having anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less,

Process for preparing an aqueous solution of a methylcellulose

A process for preparing an aqueous solution of a methylcellulose having anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups, comprises the step of mixing the methylcellulose with an aqueous liquid at a temperature of not higher than 10&#xb0; C. at a shear rate of at least 1000 s.

A sustained release dosage form comprises an active ingredient blended with a polymeric matrix. At least a portion of the polymeric matrix is formed by a cellulose ether having an onset dissolution temperature of at least 40&#xb0; C., having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26&#x2212;0.2*MS(hydroxyalkyl)] is 0.31 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Sustained release dosage forms

This invention addresses methods and compositions for providing alkyl diphenyl oxide sulfonic acid blends at useful viscosities for use in surfactants such as DOWFAX-containing surfactants. The low viscosity alkyl diphenyl oxide sulfonic acid blend is made by admixing a fatty acid having a carboxylic chain length between 1 and 12 (e.g., formic acid, acetic acid, propionic acid, butanoic acid, pentanoic acid, valeric acid, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, or dodecanoic acid into an alkyl diphenyl oxide sulfonic acid reaction product to provide between about 5 weight percentage and about 50 weight percentage of fatty acid in the admixture.

Low viscosity alkyl diphenyl oxide sulfonic acid blends

Substituted 3-thio-2-propynenitriles are prepared which correspond to the formula:

Composition and use of substituted 3-thio-2-propynenitriles as

Composition and use of substituted 3-thio-2-propynenitriles as an

A process for producing Meldrum's acid in excellent yield wherein acetic anhydride is added in a slow, controlled manner to a mixture of acetone, malonic acid and an acid catalyst.

Process for the preparation of Meldrum's acid

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Midland, MI, United States of America

David E Wallick