Bausch-lomb Incorporated

David E Seelye

Jay Friedrich Kunzler

Joseph C Salamone

Richard M Ozark

Joseph A McGee

Ivan M Nunez

David Paul Vanderbilt

Ronald E Bambury

Mahendra P Nandu

Vinod Kumar Kansal

Gary D Friends

Jay F Künzler

Keshav Deo

Jay F K&uuml;nzler

Mary Lou Friends, Legal Representative

C C Shah

Chandrakant Chunilal Shah

Dharmesh Balvantrai Mistry

Kalpesh Patel

Nilpesh Patel

Viral Parekh

Ronak Patel

Jignesh Soni

Hiral Shah

Joseph Mcgee

Crosslink agents used to copolymerize at least one hydrophilic monomer with at least one lens monomer typically used to prepare polymeric materials for ophthalmic lenses. The crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer. Accordingly, the invention is also directed to a hydrophilic crosslinked polymer that comprises at least two monomeric units and at least two different crosslink units. The use of the dual crosslink system provides an improved means to control the final chemical, physical and structural characteristics of the resulting polymer.

Crosslink agents and dual radical cure polymer

Disclosed is a process for making vinyl chloroformate which includes reacting (a) a carbonyl compound of formula I: wherein R is a halogen or an alkyl group of 1 to about 25 carbon atoms; with (b) a silyl-containing enol ether and in the presence of an effective amount of a Group VIII-containing catalyst.

Process for preparing vinyl chloroformate

Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic monomer with at least one lens monomer typically used to prepare materials for ophthalmic lenses. The new crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer.

Crosslink agents

A synthetic route to polymers comprised of at least two monomers each with a very different reactivity ratio by using a corresponding crosslink agent for each monomer. Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic monomer with at least one lens monomer typically used to prepare materials for ophthalmic lenses. The new crosslink agents have a relatively high selectivity for the hydrophilic monomer and limited reactivity with the crosslink agent used to polymerize the lens monomer.

Silicone hydrogel with composite hydrophilic and silicone polymers prepared with selective crosslink agents

A hydrogel that is the hydrated polymerization product of a monomer mixture that includes a hydrophilic monomer and a polysiloxane-containing monomer. The resulting hydrogel has an oxygen permeability of at least about 120 Barrers, a water content of at least about 20 weight percent, and a modulus from 40 to 57 g/mm.

Silicone hydrogels based on fluorinated polysiloxanes

The synthesis of benzotriazole monomers and the use of the benzotriazole monomers and one or more other monomers to prepare ultraviolet (UV) light absorbing polymer compositions. The synthetic methods described in this application provide a significant improvement over the previous methods used to prepare benzotriazole monomers.

Synthesis of benzotriazole monomer

Disclosed in embodiments herein is a method of synthesizing device forming monomers using N-(Vinyloxycarbonyloxy)succinimide.

System for synthesis of device forming monomers

The invention generally relates to methods of forming vinyl(thio)carbamates and more particularly to a vinylchloroformate-free method of synthesizing (N-vinyloxycarbonyl)-3-aminopropyltris(trimethylsiloxysilane).

Vinylchloroformate-free synthesis of vinyl and allyl(thio) carbamates

Silicone hydrogels, including vinyl carbonate endcapped polysiloxanes containing a fluorinated side chain, are useful as biomaterials, especially hydrogel biomaterials, including contact lens materials. The hydrogels are the hydrated polymerization product of a monomer mixture comprising a hydrophilic monomer and a polysiloxane-containing monomer, have an oxygen permeability of at least about 120 Barrers, a water content of at least about 20 weight percent, and a modulus no greater than about 83 g/mm.

Silicone hydrogel contact lenses

Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.

High refractive index polymeric siloxysilane compositions

Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.

Growing community of inventors

North Chili, NY, United States of America

David E Seelye