Washington University

Hoechst Celanese Corporation

University of Illinois

David E Reichert

Wei-Jen Peng

Tobias Daniel Wheeler

Paul J A Kenis

Dexing Zeng

Amit V Desai

Birce C Önal

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

A composition of matter having the formula ##STR1## wherein R.sub.1 -R.sub.14, M, l, m, and n are defined herein and which have application as MRI contrasting agents.

Tripodal aromatic heterocycle carboxamide MRI contrast agents

Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M', l, m, and n are defined herein.

Tripodal carboxamide ligands for MRI contrast agents

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St. Louis, MO, United States of America

David E Reichert