Pharmacia & Upjohn Company

Zoetis P&u LLC

David E Lowery

Teresa M Kubiak

Michael J Kennedy

Martha J Larsen

Troy E Fuller

Valdin G Smith

Timothy G Geary

Richard C Wardley

Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.

Anti-bacterial vaccine compositions with a mutated yleA gene

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Anti-bacterial vaccine compositions

The present invention providesGPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologs in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphandrotachykinin, droleucokinin, and drostatin-C receptors with their cognate peptide ligands.

The present invention provides aGPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

Drosophila G protein coupled receptors, nucleic acids, and methods related to the same

The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

G protein-coupled receptor-like receptors and modulators thereof

Attenuated mutantbacteria containing inactivated virulence genes are provided for use in safe, efficacious vaccines.

Salmonella vaccine materials and methods

The present invention provides a GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

Growing community of inventors

Portage, MI, United States of America

David E Lowery