US Government as Represented by the Secretary of the Army

USA as Represented by Secretary of the Navy

The Walter Reed Army Institute of Research

David E Lanar

Sheetij Dutta

Lisa A Ware

Evelina Angov

Jeffrey A Lyon

Lalitha P V Nair

Sanjai Kumar

Collette J Hillier

William Rogers

Arnoldo Barbosa

William c/o Dept Of State Rogers

In this application is described the expression and purification of a recombinant(3D7) LSA-NRC polypeptide. The method of the present invention produces a highly purified polypeptide which is useful as a vaccine and as a diagnostic reagent.

Expression, purification and uses of a plasmodium falciparum liver stage antigen 1 polypeptide

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In this application is the expression and purification of a recombinant(SalI) PvMSP-1 p42. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant PvMSP-1 p42 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

In this application is described the expression and purification of a recombinant(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

In this application is described the expression and purification of a recombinant(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.

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Takoma Park, MD, United States of America

David E Lanar