Janssen Pharmaceutica Nv

David E Kindrachuk

Jennifer Diane Venable

James Patrick Edwards

Daniel J Buzard

Daniel J Pippel

Michael D Hack

Christopher M Mapes

Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, including allergy, asthma, autoimmune diseases, and pruritis.

Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor

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Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for Hreceptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, including allergy, asthma, autoimmune diseases, and pruritis.

Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as Hreceptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine Hreceptor activity and for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating Hreceptor expression, and in treating conditions such as inflammation, Hreceptor-mediated conditions, and related conditions.

Imidazole compounds

Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating Hreceptor, and in treating conditions such as inflammation, Hreceptor-mediated conditions, and related conditions.

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Cardiff by the Sea, CA, United States of America

David E Kindrachuk