University of Manitoba

David E Herbert

Zihan Qiu

Jason D Braun

Bin Huang

Issiah B Lozada

Yaorong Zheng

The present disclosure relates to new metal complexes, including derivatives thereof, methods of making the metal complexes, and uses thereof, including uses, for example, as photosensitizers and as photocatalysts. In an embodiment, a metal complex having the structure of Formula (I): a salt, hydrate, solvate, tautomer, optical isomer, or combination thereof.

Metal complexes, methods of making the same, and uses thereof

Described herein is the development of synthetic routes to produce a wide variety of substituted phenanthridines, specifically, multidentate phenanthridine-containing ligand frameworks capable of anchoring to Pt via more than one binding site and with the phenanthridinyl moiety co-planar to the coordination plane of Pt. The multidentate chelation is designed to attenuate the reactivity of the platinum complex in vivo, and ultimately help mitigate side effects. In addition, the geometry of phenanthridine binding to the metal centre is altered compared to in phenanthriplatin, thanks to the constraints of the ligand geometry. By enforcing coplanar binding with the metal's square planar coordination plane, these compounds exhibit altered modes of activity, and should hence enhance/change the spectrum of activity of our prodrug candidates compared with phenanthriplatin.

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Winnipeg, Canada

David E Herbert