Boehringer Ingelheim Vetmedica Gmbh

University of Minnesota

South Dakota State University

Other

Boehringer Ingelheim Animal Health, Inc.

United States of America, As Represented by the Secretary of Agriculture

Boehringer Ingleheim Vetmedica, Inc.

United States Department of Agriculture

David E Gorcyca

Danny W Chladek

Louis L Harris

David A Benfield

James E Collins

Kelly M Lager

Mike Roof

William L Mengeling

Ann C Vorwald

Kelly Burkhart

Kelly Lager

Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation. The present invention also provides diagnostic testing methods which can differentiate between animals infected with field strains and attenuated strains of PRRSV.

Porcine reproductive and respiratory syndrome vaccine based on isolate JA-142

The invention includes kits for producing and using immunogenic compositions that include swine infertility and respiratory virus. The invention also includes vaccines and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic 'mystery swine disease' and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

Kits for detecting anti-SIRS antibodies

Porcine reproductive and respiratory syndrome vaccine, based on isolate JA-142

Immunogenic compositions that include SIRS virus

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic 'mystery swine disease' and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

Kits for detecting swine infertility and respiratory syndrome (SIRS) virus

Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation.

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic &ldquo;mystery swine disease&rdquo; and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

Method for detecting swine infertility and respiratory virus

Immunogenic composition containing inactivated swine infertility and respiratory Syndrome virus

Vaccine for swine infertility and respiratory syndrome and method of use

Method of producing a vaccine for Swine Infertility and Respiratory

A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.

Viral agent associated with mystery swine disease

Culture of swine infertility and respiratory syndrome virus in simian

Growing community of inventors

St. Joseph, MO, United States of America

David E Gorcyca