Sri International

Other

Gas Research Institute

Orasure Technologies, Inc.

David E Cooper

James G Kane

Norman A Peppers

Luke V Schneider

Mark J Dyer

David A Zarling

R Sam Niedbala

Steve Y Ng

Gregory W Faris

Keith W Kardos

Michel J Rossi

Pajo Vujkovic-Cvijin

Jarrett Lee Burton

Clinton B Carlisle

Haris Riris

Pablo E Garcia

Mark David Steele

Thomas Andrew Shaler

Hua Lin

Jan E Van Der Laan

Estevan Mendoza

Roger H Schmidt

Thomas F Gallagher

Annalisa D'Andrea

Polly Chang

Travis Harrison

Jan E Ver Der Laan

Robert Balog

Sylvie Carlisle

Christina Swanson

Russell E Warren

Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.

Biomarker panel for dose assessment of radiation injury and micro plasma filter

This specification discloses a method and apparatus for the mobile and remote detection of a gas, such as methane, in the atmosphere. The apparatus includes a TDL based Light Detection and Ranging (LIDAR) driven at carrier frequency lying within the absorption line of the gas. The apparatus also drives the TDL with a modulation frequency to generate upper and lower sidebands in the output of the TDL and with a low ramp frequency to sweep the output of the TDL across twice the width of the pressure-broadened absorption line of the gas, preferably the first overtone absorption line in the case of methane detection. The apparatus include reference and calibration cells or chambers, and includes a light collector and detectors to detect the quantity and modulation of the light that passes the reference or calibration cells and that is received by the apparatus after reflection back toward the apparatus from an uncooperative target. The apparatus further includes a signal processor that applies a derivative spectroscopy technique, such as frequency modulation spectroscopy or wavelength modulation spectroscopy, to determine the presence of the gas in the atmosphere.

Apparatus and method of remote gas trace detection

A high performance reconfigurable DWDM transmitter incorporates discrete optical components placed in v grooves etched in a substrate. Direct wavelength monitoring can be achieved with wavelength modulation locking applied independently to a gas absorption line and to etalon fringes. A set of equally-spaced wavelengths may be provided by a set of lasers, or a single laser can be used for a number of fixed frequencies.

Reconfigurable multichannel transmitter for dense wavelength division multiplexing (DWDM) optical communication

This specification discloses a method and apparatus for the mobile and remote detection of a gas, such as methane, in the atmosphere. The apparatus includes a TDL based Light Detection and Ranging (LIDAR) driven at carrier frequency lying within the absorption line of the gas. The apparatus also drives the TDL with a modulation frequency to generate upper and lower sidebands in the output of the TDL and with a low ramp frequency to sweep the output of the TDL across twice the width of the pressure-broadened absorption line of the gas, preferably the first overtone absorption line in the case of methane detection. Suitable power for remote detection through use of the TDL is provided by a master oscillator/fiber amplifier transmitter has no moving or adjustable parts at all. An all-solid-state monolithic and integrated amplifier is achieved, which leads to a compact and virtually maintenance-free LIDAR system. The remote detection apparatus includes reference and calibration cells or chambers, and includes a light collector and detectors to detect the quantity and modulation of the light that passes the reference or calibration cells and that is received by the apparatus after reflection back toward the apparatus from an uncooperative target. The apparatus further includes a signal processor that applies a derivative spectroscopy technique, such as frequency modulation spectroscopy or wavelength modulation spectroscopy, to determine the presence of the gas in the atmosphere.

The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

Up-converting reporters for biological and other assays

RF modulation spectroscopy of a near-infrared tunable laser diode source is used to determine the oxygen concentration in a sample medium. A reference cell containing a known concentration of oxygen is used to calibrate the apparatus as well as to lock the laser on an oxygen absorption line. The temperature of the reference cell is monitored from which the pressure in the reference cell can be determined. Both the temperature and the pressure in the sample cell are monitored, either directly using independent transducers or indirectly using spectroscopic techniques. The oxygen content of the sample is determined, correcting for both temperature and pressure effects.

Pressure- and temperature-compensating oxygen sensor

A sleep awakening device awakens drivers of motor vehicles who are falling asleep while driving. The sleep awakening device includes a pair of eyeglasses and a control unit electrically connected thereto to provide both visual and audible warnings to alert a driver who is falling asleep. The pair of eyeglasses include a sensing lever that is in constant contact with one of the driver's upper eyelid muscles. Downward motion of the eyelid moves the sensing lever downward and actuates a microswitch that is coupled to the sensing lever. The microswitch in turn actuates circuitry located in the control unit to turn on a light each time the driver closes his eyelid. The circuitry includes a time delay relay that initiates an audible signal if the eyelid remains closed for a preset period of time. A normal blink of a driver's eye does not produce an audible alarm. However, if the driver's eyelid fails to open in a predetermined time, the audible alarm will sound. As soon as the driver's eyelid opens, a yellow caution light and the audible alarm are reset. Normal eye blinks produce illumination of the yellow caution light in view of the driver, thereby assuring the driver that the sleep awakening device is functioning properly.

Sleep awakening device for drivers of motor vehicles

RF modulation spectroscopy of a near infrared laser diode source is used to determine the amount of a target substance in a breath sample. In this type of modulation the laser output is modulated to produce sidebands displaced from the laser carrier by the modulation frequency. The modulated beam is passed through a gas sample which differentially absorbs the sidebands, the result of which is the conversion of some of the laser frequency modulation into amplitude modulation which is subsequently detected using a broadband photodetector. In certain tests, the target substance is a particular isotope, whose concentration is measured as an isotope ratio. In order to measure the presence of first and second isotopic species, provision is made to provide laser illumination at characteristic wavelengths for absorption lines for the first and second isotopic species of the gas. This may sometimes be accomplished using a single laser diode and scanning at least one of its operating parameters in order to achieve one of the wavelength difference. Alternatively, first and second laser diodes operating at the first and second wavelengths are used.

Diagnostic tests using near-infrared laser absorption spectroscopy

A spectroscopic technique in which the sample under investigation is probed with a generally monochromatic beam of light which has been modulated at two distinct modulation frequencies. The double modulation produces a plurality of sidebands, and the two modulation frequencies are related to one another such that a selection of sidebands falls into two groups of closely spaced component sidebands. A first group is disposed in frequency at the spectral feature of interest and serves to probe the spectral feature. The other group is disposed in frequency remote from the feature and serves as a reference group. Within each group the component sidebands are offset from one another by a characteristic offset frequency, which can be considerably less than the width of the spectral feature under investigation. After interaction with the sample the doubly modulated beam is passed on to a photodetector, which in combination with appropriate signal processing apparatus detects a signal at the characteristic offset frequency representative of the spectral feature.

Method and apparatus for double modulation spectroscopy

An inverted channel member is placed over a surface having particulate or similar matter upon it. Air is forced through the channel member to create a vacuum within the member which causes the matter upon the surface to be picked up and blown from the surface and out the channel member.

Device for removing liquid and similar matter from a surface

Growing community of inventors

Palo Alto, CA, United States of America

David E Cooper