Dendreon Corporation

Mei Pharma, Inc.

Corvas International, Inc.

David Duncan

Sateesh Kumar Natarajan

Joseph Edward Semple

Reiner Laus

Thomas Graddis

Feng Chen

Edwin L Madison

Odile Esther Levy

Terence Kevin Brunck

Marguerita S Lim-Wilby

Mallareddy Komandla

Kent Pryor

Amir P Tamiz

Ronald D Lewis, Ii

L Josue Alfaro-Lopez

C Maxwell Lawrence

The disclosure relates to crystalline solid forms of voruciclib, including voruciclib free base and various voruciclib salts, pharmaceutical compositions containing voruciclib crystalline solid forms, and methods for treating conditions or disorders by administering pharmaceutical compositions including voruciclib crystalline solid forms.

Voruciclib polymorphs and methods of making and using thereof

Crystalline polymorph forms of 3-[2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acrylamide are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of diseases and conditions are also presented.

Polymorphic forms of 3-[(2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acrylamide and uses thereof

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

Small-molecule modulators of Trp-p8 activity

Compositions and methods for the treatment of disease associated with TRP-P8 expression

Compositions and methods for the treatment of disease associated with Trp-p8 expression

Small-molecule modulators of TRP-P8 activity

Small-molecule modulators of TRP-p8 activity

The present invention provides matriptase inhibitors and compositions thereof useful for treating cancer. Martripase is a trypsin-like serine protease active in the development of cancerous conditions, such as tumors and metastasis of cancer.

Matriptase inhibitors and methods of use

Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones and benzophenones are provided.

Plasminogen activator inhibitor antagonists

Growing community of inventors

San Diego, CA, United States of America

David Duncan