Quantum-si Incorporated

David Dodd

Jonathan Marc Rothberg

Jeremy Lackey

Brian Reed

Haidong Huang

Xinghua Shi

Jonathan M Rothberg

Roger Nani

Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.

Biconjugatable labels and methods of use

Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

High intensity labeled reactant compositions and methods for sequencing

Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

Growing community of inventors

Guilford, CT, United States of America

David Dodd