Washington University

The Council of the Queensland Institute of Medical Research

The Albert B. Sabin Vaccine Institute

David Diemert

Jeffrey Bethony

Maria Elena Bottazzi

Alexander Loukas

Gaddam Goud

Bin Zhan

Peter Hotez

Ami Shah Brown

Mark Pearson

Peter Giacomautonio

A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens areantigens, although antigens from other hookworm species (e.g.) may also be employed. The schistosome antigen is preferably aor aantigen although antigens from other schistosome species (e.g.) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {) to produce recombinant chimeric antigens.

Multivalent antihelminthic vaccine

Growing community of inventors

Washington, DC, United States of America

David Diemert