Akzo N.v.

Akzona Incorporated

David De Wied

Hendrik M Greven

The present invention relates to peptides having psychopharmacological properties, of the formula: ##STR1## wherein A represents the aminoacid residue Arg, Lys or Leu and

Peptides

The invention relates to the use of (2-9)-.alpha.-endorfine for dopaminergic and vasopressin-releasing properties.

Methods of treating patients using a pharmaceutical preparation

The present invention relates to peptides with psychopharmacological properties of the formula ##STR1## wherein R represents ##STR2## A represents the amino acid residue Arg, Lys or Leu and Y represents the group OH or the group Gly-OH, as well as functional derivatives thereof.

The present invention is dealing with a pharmaceutical composition containing a peptide of the formula:

Biologically active peptides

The present invention relates to novel psycho-pharmacological active peptides and peptide derivatives of the formula:

Psycho-pharmacological peptides

Novel and biologically useful peptides of the formula: A.sub.1 -A.sub.2 -L-Phe-X-L-Thr-L-Ser-R.sub.1 -Y-L-Ser-R.sub.2 -L-Thr-L-Pro-L-Leu-L-Val-L-Thr-B are disclosed (together with pharmaceutical compositions comprising a pharmaceutically effective amount of same) wherein:

Psychopharmacological peptides

Biologically active novel peptide compounds are disclosed of the formula

Peptide derivatives and pharmaceutical compositions containing same

Biologically active novel peptides and peptide-derivatives of the general formula: ##STR1## where A represents H-(L or D)Met, H-(L or D)Met(.fwdarw.O), H-(L or D)Met(.fwdarw.O.sub.2)

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Bilthoven, Netherlands

David De Wied