Bend Research, Inc.

Pfizer Corporation

Emd Millipore Corporation

David D Newbold

Dwayne Thomas Friesen

Roderick Jack Ray

Douglas Lee Millard

Scott B McCray

John Michael Baumann

Daniel Elmont Dobry

Devon B DuBose

Devon Dubose

Paul T Jeffers

Jeffrey W Weber

James Mathew Mullin

Erwin Yaokui Yu

David J Edlund

James William West

David Keith Lyon

Marshall David Crew

Leah Elizabeth Appel

Avinash G Thombre

Ronald Arthur Beyerinck

Joshua R Shockey

Chester B Frost

Christopher D Craig

Kenny R Spence

George Lewis Ellis, Jr

Kevin Douglas Grove

Lori A Ray

Raymond H Colton

Richard W Schofield

Douglas L Millard

Mark S Carruthers

Erwin Y Yu

A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.

Automatic aseptic sampling valve for sampling from enclosed containers

The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T, wherein Tis greater than T, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T, such that the active agent and matrix material are soluble in the organic solvent at T.

Spray-drying process

Fixed volume aseptic sampling valve for sampling from enclosed containers

A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

Spray-drying apparatus and methods of using the same

Automatic sampling system for sampling from enclosed containers

A secondary drying process is disclosed for removing residual solvent from drug-containing particles that have been formed by solvent-based processes, the secondary drying process utilizing a combination of vacuum, agitation, and a stripping gas.

Drying of drug-containing particles

The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T, wherein Tis greater than T. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.

High-temperature spray drying process and apparatus

Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.

Extrusion process for forming chemically stable drug multiparticulates

A laser drilling system forms an opening in the coating of a pharmaceutical dosage form and includes an orienting assembly to correctly orient dosage forms, a debris removal assembly to reduce buildup of and reduce exposure to drilling debris and a quality control assembly to verify that the opening formed conforms to predetermined specifications.

Pharmaceutical laser drilling system

A system for the ultrapurification of organic solvents comprising (1) a membrane-based vapor permeation step for selective removal of water vapor from the solvent, wherein a countercurrent sweep stream is used that has a particular partial pressure of water vapor, (2) a filtration step for selective removal of particulates, and (3) an ion exchange step for selective removal of ionic species.

Ultrapurification of organic solvents

Membrane-based vapor permeation system for selective removal of a vapor from a fluid feed stream, wherein a countercurrent sweep stream is used that has a particular partial pressure of the vapor to be removed.

Vapor permeation system

Growing community of inventors

Bend, OR, United States of America

David D Newbold