Medical Concepts Development, Inc.

Other

Covalent Medical, Inc.

David D Cox

Leland W Annett

Robert E Lund

Frank A DeLustro

Johan Lowinger

Bruno Lowinger

David A Browdie

A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

Tissue adhesive sealant

An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The adhesive composition is essentially solventless and capable of application in a hot melt process while maintaining stability at elevated temperatures in the range of 275&deg; F. to 350&deg; F., which not only allows hot melt application, but allows for ethylene oxide sterilization under heat stress.

Antimicrobial containing solventless hot melt adhesive composition

An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The adhesive composition is essentially solventless and capable of application in a hot melt process while maintaining stability at elevated temperatures in the range of 275.degree. F. to 350.degree. F., which not only allows hot melt application, but allows for ethylene oxide sterilization under heat stress.

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Woodbury, MN, United States of America

David D Cox