Modulated Imaging, Inc.

Other

University of California

David Cuccia

Amaan Mazhar

Bruce J Tromberg

Anthony J Durkin

Frederic Bevilacqua

Bernard H Choi

Systems and methods directed to the assessment of circulatory complications due to advancement of diabetes. Embodiments include an optical measurement device having a light source with one or more wavelengths and configured to illuminate an area of tissue, a detector configured to capture the light reflecting from one or more layers of the tissue at the one or more illumination wavelengths, a processor configured to compute, based on the detected signal of layer extracted circulatory data, one or more estimates of tissue vascular health, and a display or communication device (e.g., electronic data transfer) configured to store or report the tissue vascular health. In exemplary embodiments, the distribution of chromophores such as hemoglobin in different layers of skin is extracted using a combination of structured light in the visible and near-infrared regime.

Systems and methods for assessing diabetic circulatory complications

Systems and methods directed to the assessment of tissue vascular health. An optical measurement device includes a light source with one or more wavelengths, configured to illuminate an area of tissue, a detector configured to capture the light reflecting from the tissue at the one or more illumination wavelengths, a processor configured to compute, based on the detected signal, one or more estimates of tissue vascular health, and a display or communication device (e.g., electronic data transfer) configured to store or report the tissue vascular health.

Method and apparatus for assessing tissue vascular health

An apparatus for turbid sample measurement comprising a plurality of light sources for illuminating a turbid sample target area with non-spatial structured light, a projection system for illuminating the turbid sample target area with spatial structured light, a sensor for collecting light from the turbid sample target area, and a processor to analyze the data captured by the sensor to yield scattering and absorption coefficients of the turbid sample. A method comprises illuminating the sample with spatial structured light, collecting light reflected from the sample at a number of wavelengths, illuminating the sample with non-spatial structured light, collecting light reflected from the sample at a number of wavelengths, and combining the measurements of the collected light to obtain the optical properties of the sample and/or the concentration of absorbing or fluorescent molecules. The wavelengths of the spatial and non-spatial light sources are preferably different.

Efficient modulated imaging

Method and apparatus for obtaining qualitative and quantitative analysis of the optical properties or structures of tissue or turbid medium at one or more wavelengths via 1) detection at a single spatial location on the surface of a turbid medium (such as tissue) under two or more structured light conditions or 2) detection at two or more spatial locations on the surface under a single structured light condition.

Method and apparatus for analysis of turbid media via single-element detection using structured illumination

An apparatus for wide-field functional imaging (WiFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging

A method and an apparatus for noninvasively and quantitatively determining spatially resolved absorption and reduced scattering coefficients over a wide field-of-view of a food object, including fruit or produce, uses spatial-frequency-domain imaging (SFDI). A single modulated imaging platform is employed. It includes a broadband light source, a digital micromirror optically coupled to the light source to control a modulated light pattern directed onto the food object at a plurality of selected spatial frequencies, a multispectral camera for taking a spectral image of a reflected modulated light pattern from the food object, a spectrally variable filter optically coupled between the food object and the multispectral camera to select a discrete number of wavelengths for image capture, and a computer coupled to the digital micromirror, camera and variable filter to enable acquisition of the reflected modulated light pattern at the selected spatial frequencies.

Method and apparatus for performing qualitative and quantitative analysis of produce (fruit, vegetables) using spatially structured illumination

An improvement in a method for quantitative modulated imaging to perform depth sectioned reflectance or transmission imaging in a turbid medium, such as human or animal tissue is directed to the steps of encoding periodic pattern of illumination preferably with a fluorescent excitation wavelength when exposing a turbid medium to the periodic pattern to provide depth-resolved discrimination of structures within the turbid medium; and reconstructing a non-contact three dimensional image of the structure within a turbid medium. As a result, wide field imaging, separation of the average background optical properties from the heterogeneity components from a single image, separation of superficial features from deep features based on selection of spatial frequency of illumination, or qualitative and quantitative structure, function and composition information is extracted from spatially encoded data.

Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography

A calf/foot support and treatment table for extension, flexion, traction, distraction and lateral movement of the body of a patient includes a base adapted to rest upon a floor, and a system support assembly having an upper end and a lower end integrally secured to the base, a rigid support platform having a lower part and an upper part, the support platform pivotally secured to a pivot axle of said system support assembly; a lumbar support assembly disposed on the lower part of the support platform; and a calf/foot support assembly for linear traction.

Foot and calf support and adjustment assembly

Illumination with a pattern of light allows for subsurface imaging of a turbid medium or tissue, and for the determination of the optical properties over a large area. Both the average and the spatial variation of the optical properties can be noninvasively determined. Contact with the sample or scanning is not required but may be desired. Subsurface imaging is performed by filtering the spectrum of the illumination in the Fourier domain but other filtering approaches, such as wavelet transform, principle component filter, etc may be viable as well. The depth sensitivity is optimized by changing the spatial frequency of illumination. A quantitative analysis of the average optical properties and the spatial variation of the optical properties is obtained. The optical properties, i.e. reduced scattering and absorption coefficients are determined from the modulated transfer function, MTF.

Method and apparatus for performing quantitative analysis and imaging surfaces and subsurfaces of turbid media using spatially structured illumination

A foot-and-calf support and treatment table for extension, flexion, traction, distraction and lateral movement of the spine and lower body of a patient includes a base adapted to rest upon a floor, and a system support assembly having an upper end and a lower end integrally secured to the base, the support assembly including a pivot axis proximal to upper end. The treatment table also includes a selectable reciprocal extension element having an upper end and a lower end, one end pivotally attached to the system support assembly, the selectable extension elements providing reciprocal movement of the one end relative to an opposite end. The table further includes a rigid support platform having an upper end and a lower end, the platform pivotally secured to the pivot axis of the support assembly and, further, pivotally secured to the one end of the selectable extension element to provide a resultant rotational motion of the support platform. The treatment table yet further includes a body support assembly adjustably positionable relative to the rigid support platform, the assembly having an upper end and a lower end; and an assembly for enabling the patient to remain on the body support assembly during rotational movement.

Calf and foot support and adjustment assembly

A rotatable chiropractic treatment table for extension, flexion, traction, distraction and lateral movement of the spine of a patient includes a base adapted to rest upon a floor, and a system support assembly having an upper end and a lower end integrally secured to the base, the support assembly including a pivot axis proximal to upper end. The treatment table also includes a selectable reciprocal extension element having an upper end and a lower end, one end pivotally attached to the system support assembly, the selectable extension elements providing reciprocal movement of the one end relative to an opposite end. The table further includes a rigid support platform having an upper end and a lower end, the platform pivotally secured to the pivot axis of the support assembly and, further, pivotally secured to the one end of the selectable extension element to provide a resultant rotational motion of the support platform. The treatment table yet further includes a body support assembly adjustably positionable relative to the rigid support platform, the assembly having an upper end and a lower end; and an assembly for enabling the patient to remain on the body support assembly during rotational movement.

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Costa Mesa, CA, United States of America

David Cuccia