Janssen Sciences Ireland Uc

Tibotec Pharmaceuticals Ltd.

Janssen Sciences Ireland Unlimited Company

Medivir Ab

Janssen R&d Ireland

David Craig Mc Gowan

Pierre Jean-Marie Bernard Raboisson

Tim Hugo Maria Jonckers

Stefaan Julien Last

Serge Maria Aloysius Pieters

Abdellah Tahri

Koen Vandyck

Jean-François Bonfanti

Sandrine Marie Helene Vendeville

Lili Hu

Herman Augustinus De Kock

Dominique Louis Nestor Ghislain Surleraux

Werner Embrechts

Werner Constant Johan Embrechts

Wim Gaston Verschueren

Anil Koul

Jerôme Emile Georges Guillemont

Magali Madeleine Simone Motte

Ludwig Paul Cooymans

Bengt Bertil Samuelsson

Jérôme Michel Claude Fortin

Wendy Mia Albert Balemans

Jérôme Émile Georges Guillemont

Karl Magnus Nilsson

Philippe Muller

Christophe Francis Robert Nestor Buyck

Frédéric Marc Maurice Doublet

Geerwin Yvonne Paul Haché

Edgar Jacoby

Guillaume Jean Maurice Mercey

Wim Van De Vreken

Geert Rombouts

Antoine Benjamin Michaut

Dmitry Antonov

Pierre Jean-Marie Raboisson

Anna Karin Gertrud Linnea Belfrage

Jaromir Vlach

Carl Erik Daniel Jönsson

Mourad Daoubi Khamlichi

Susana Ayesa Alvarez

Werner Constant J Embrechts

Florence Marie Herschke

Serge Marie Aloysius Pieters

Jean-Francois Bonfanti

Steffen Friedrich Walter Weidner

Bart Henri Theresia Stoops

Emilie Marie Lambert

Jacques Armand Henri Bollekens

David Francis Alain LANÇOIS

Laurent Jacques Emile Calmus

Geerwin Yvonne Paul HachÉ

ÅSa Annica Kristina Rosenquist

Kenneth Alan Simmen

Tim Hugo Jonckers

Serge Maria Pieters

Jerome Emile Guillemont

Jérôme ÉMile Georges Guillemont

Magali Madeleine Motte

Wendy Mia Balemans

David Francis Lancois

Geerwin Yvonne Hache

Werner Constant Embrechts

Jerome Michel Fortin

Frederic Marc Doublet

Steffen Friedrich Weidner

This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy. In formula (I), Ris a Calkyl, optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, amino, nitrile, ester, amide, Calkyl, or Calkoxy, the carbon of Rbonded to the amine in the 4-position of the quinazoline is in (R)-configuration, Ris hydrogen, deuterium, fluorine, chlorine, methyl, methoxy, cyclopropyl, trifluoromethyl, or carboxylic amide, wherein each of methyl, methoxy and cyclopropyl is optionally substituted by one or more substituents independently selected from fluorine and nitrile, Ris hydrogen or deuterium, Ris hydrogen, deuterium, fluorine, methyl, carboxylic ester, carboxylic amide, nitrile, cyclopropyl, Cheterocycle, or 5-membered heteroaryl group, wherein each of methyl, cyclopropyl, Cheterocycle and 5-membered heteroaryl group is optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, or methyl, Ris hydrogen, deuterium, fluorine, chlorine, methyl, or methoxy, provided that at least one of R, R, Rand Ris not hydrogen. 

2,4-diaminoquinazoline derivatives and medical uses thereof

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

Pyrimidine derivatives for the treatment of viral infections

Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Rto Rand Rto Rhave the meaning as defined herein. The present invention also relates to processes for preparing compounds of Formula (ID), pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

This invention relates to acylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.

Substituted acylaminopyrimidines as inducers of alpha interferon production

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV. 

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Y, R, R, Rand n have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy. 

Macrocyclic indole derivatives useful as hepatitis C virus inhibitors

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Brussels, Belgium

David Craig Mc Gowan