National Institutes of Health, a Component of the US Dept. of Health & Human Services

Other

David Covell

Ettore Appella

Susan Elaine Bates

William G Rice

John K Inman

Mingjun Huang

James A Turpin

Melinda G Hollingshead

Susan D Mertins

Geoffrey W Patton

Rao Vishnuvajjalla

Yongsheng Song

Anders Wallqvist

Andrew Maynard

John A Beutler

Ranjala Ratnayake

Tanya R Johnson

Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plantor produced by synthetic methods. An example of the englerin derivative is 2'-chloroenglerin A, which has the structure (II), wherein double bond 'a' is E, Z, or a mixture of E and Z. 

Epoxy-guaiane derivatives and treatment of cancer

The present invention features methods of treating a mammalian subject having renal cancer by administration of 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.

Treating renal cancer using 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde

The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.

Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde

This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

Thiolesters and uses thereof

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Chevy Chase, MD, United States of America

David Covell