Emulate, Inc.

Janssen Biotech, Inc.

David Conegliano

Daniel Levner

Christopher David Hinojosa

Norman Wen

Geraldine A Hamilton

Antonio Varone

Catherine Karalis

Riccardo Barrile

Justin Nguyen

Jacob Fraser

Hyoungshin Park

Andries Van Der Meer

Monicah Otieno

Josiah Daniel Sliz

S Jordan Kerns

Jefferson Puerta

Brian Zuckerman

Tanvi Shroff

Grace Ahn

Jonathan Rubins

Victor Antontsev

Carolina Lucchesi

Remi Villenave

Janna Nawroth

Hyoung Shin Park

The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.

Compound distribution in microfluidic devices

An in vitro microfluidic 'organ-on-chip' device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.

Stem cell-based lung-on-chip models

Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it 'on-chip' before moving into the experimental region of the chip.

Additive channels

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Boston, MA, United States of America

David Conegliano