Burroughs Wellcome Co.

David Collard

Frederick C Copp

Albert G Caldwell

Alexander D Frenkel

Peter T Roberts

Clive V Denyer

Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation. The compounds may be prepared by methods analogous to those known in the art, e.g., by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis

Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation. The compounds may be prepared by methods analogous to those known in the art, e.g. by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

Antiinflammatory pyrazole thioureas

1-Phenoxyalkyl- and 1-anilinoalkyl imidazolines, methods for the preparation thereof, the use thereof as intermediates and pesticides and pesticidal formulations containing such compounds.

Pesticidal anilinomethylimidazolines

Amides

Compounds of formula (I): ##STR1## wherein Ar is an unsubstituted or mono-, di or tri-substituted phenyl radical in which the substituents are the same or different and are selected from alkyl, alkoxy, halogen, hydroxy, cyano, amino, trifluoromethyl or nitro and in which any two adjacent carbon atoms on the phenyl ring may optionally be joined by a carbon chain having 3 or 4 carbon atoms;

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Beckenham, United Kingdom

David Collard