Chiesi Farmaceutici S.p.a.

David Chauvier

Richard Casimir

Johan Hoebeke

Etienne Jacotot

Dominique Rebouillat

Annie Borgne

Alain Langonne

Hervé Lecoeur

The present disclosure relates to peptides having a core sequence as described herein as well as application of the disclosed technology as inhibitors of caspase-2 and/or -6 activity.

Peptides useful as dual caspase-2/-6 inhibitors and their biological applications

The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2. 

Caspase-2 inhibitors and their biological applications

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Limeil-Brevannes, France

David Chauvier