University of California

University of Rhode Island

University of Rhode Island Research Foundation

David C Rowley

William H Fenical

Paul R Jensen

William H Gerwick

David R Nelson

Navindra Seeram

Jennifer Smith

Lena Gerwick

Robert Deering

Hyuakjae Choi

Paul Cohen

Jiadong Sun

Francisco Villa

Marta Gomez-Chiarri

Jason LaPorte

The invention provides a method and related compositions for preparing an effective probiotic bacteria formulation that can be stored, transported and used for protecting a variety of marine organisms against infection by potential pathogens.

Marine bacteria formulation useful in aquaculture

The present invention provides compositions derived from cranberry including xyloglucan and pectic oligosaccharides, and iridoid terpene glycosides. These compositions can be used in conjunction with antibiotics to synergistically kill bacterial persister cells and inhibit bacterial quiescent phenotypes, thereby improving treatment outcomes in recurrent and other infections.

Cranberry-derived compositions for potentiating antibiotic efficacy against bacterial persistence

The invention provides novel compositions based on a structure designated as 'Honaucin A', including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.

Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them

Halovir, an antiviral marine natural product, and derivatives thereof

Growing community of inventors

La Jolla, CA, United States of America

David C Rowley