N.v. Organon

Organon N.v.

David C Rees

John Richard Morphy

Friedrich Kroll

David Gani

Michael John Plater

Alan William Muir

Antonius Helena Adolf Bom

The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) wherein R is (a), (b) or (c); or general formula (B) wherein X is (a), (b) or (d), or a pharmaceutically acceptable salt thereof.

Use of chemical chelators as reversal agents for drug-induced neuromuscular block

There is provided a polymer having a side chain of general formula (I) in which R may be any suitable alkyl, oxyalkyl, aryl or oxyaryl linking group R is preferably Calkyl (especially &#x2014;CH&#x2014;), a benzene group or a group &#x2014;CH&#x2014;O-Phe-. Generally, the side chain will be attached to an ethylene moiety forming part of the backbone of the polymer. Preferred polymers include polystyrene. The polymer is useful as a support for solid phase chemical reactions especially combinatorial chemical synthesis. 

Vinyl sulphone modified polymer

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Västra Frölunda, Sweden

David C Rees