The International Heart Institute of Montana Foundation

University of Montana

David C Pang

David T Cheung

Carlos M G Duran

Edward Rosenberg

A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25% by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (<1000 D) polyethylene glycol, and polyethylene glycol of a molecular weight between approximately 6,000 to 15,000 D and heparin. Thereafter, the tissue specimen is briefly immersed in aqueous heparin solution, frozen and lyophilized. The tissue specimen is suitable for implantation as a homograft or xenograft, with or without rehydration.

Compliant dehyrated tissue for implantation and process of making the same

An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host mammal and to render the tissue temporarily more rigid than in its native state, and better suited for shaping, molding, handling and cutting prior to implantation into the host patient. The implant is highly resistant or immune to thickening, contraction and reduced fibrin deposition after it is implanted and exposed to the bloodstream of the host.

Solution and method for treating autologous tissue for implant operation

Compliant dehydrated tissue for implantation and process of making the same

A process for removing ions of dissolved heavy metals and complex heavy metals comprises provides a treatment zone in which is contained an extraction material having an activated surface that has an affinity for heavy metal ions and complex heavy metal ions. The activated surface is the reaction product of a polyamine with a covalently anchored trifunctional hydrocarbyl silyl that yields non-crosslinked amino groups to which functional chelator groups can be covalently attached. The activated surface of the extraction material is formed by first hydrating the extraction material surface and then silanizing the hydrated surface with a short chain trifunctional silane having a hydrocarbon substituent containing 1-6 carbon atoms and a terminal leaving group, and then reacting a polyamine with the hydrocarbylsilyl from the silanization of the hydrated surface so as to form an aminohydrocarbyl polymer covalently bound to the extraction material surface.

Growing community of inventors

Missoula, MT, United States of America

David C Pang