Amgen Inc.

Onyx Therapeutics, Inc.

Cytokinetics, Inc.

Syros Pharmaceuticals, Inc.

David C Moebius

Dustin L McMinn

Alan C Cheng

Mikkel V Debenedetto

Henry Johnson

Bradley Paul Morgan

Chihyuan Chuang

Luke W Ashcraft

Michael G Johnson

Felix Gonzalez Lopez De Turiso

Scott E Collibee

Simeon Bowers

Russell Graceffa

Alessandro Boezio

Antonio Romero

David Joseph St Jean, Jr

Richard Vargas

Joshua Payette

John R Butler

Hanmo Zhang

Aroop Chandra

Justin Malinowski

John Yeoman

Vincent DiMassa

Dustin Mcminn

Jonathan B Houze

Stephane Ciblat

Zhihua Ma

Paul John Dransfield

Clint A James

Yi Zhang

Vatee Pattaropong

Jason J Marineau

Su-Jen Lai

Charles Kreiman

Gayathri Swaminath

Yinhong Chen

Aarif Yusuf Khakoo

Huiping Amy Guan

James S Harvey

Claudio Edmundo Chuaqui

Goran Malojcic

William Sinko

Ankit Sharma

Sylvain Bernard

Amandine Xolin

Malay Doshi

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Bisamide sarcomere activating compounds and uses thereof

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. 

Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Tripeptide epoxy ketone protease inhibitors

Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer.

Pyrrolotriazine compounds and methods of inhibiting TAM kinases

Bisamide sarcomere activating compounds and uses therof

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein. 

Triazole pyridyl compounds as agonists of the APJ receptor

Peptide epoxyketone immunoproteasome inhibitors

Provided herein are dipeptide and tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of proliferative diseases including cancer and autoimmune diseases. 

Dipeptide and tripeptide epoxy ketone protease inhibitors

Growing community of inventors

Foster City, CA, United States of America

David C Moebius