Eli Lilly and Company

David C Hunden

Gary A Koppel

Robert F Bruns, Jr

Jeffrey J Skelton

Charles David Jones

Jill A Panetta

Bruce Anthony Dressman

Stephen W Kaldor

Mitchell I Steinberg

John Robert Rizzo

Walter N Shaw

Juliana Maude Bue-Valleskey

Robin D Cooper

Edward R Lavagnino

Robin D G Cooper

Bennie J Foster

Michael O Chaney

Non-peptidyl vasopressin V1A antagonists

Non-peptidyl vasopressin V1a antagonists

This invention provides methods and 2-(azetidin-2-on-1-yl)acetic acid derivatives for the antagonism of the vasopressin V,receptor.

This invention relates to a combinatorial process for synthesizing a library of azetidinone peptide-like compounds. The compounds are synthesized as mixtures from a common azetidinone intermediate. The compounds are biologically active as inhibitors of the Vasopressin (V1a) receptor.

Combinatorial process for synthesizing azetidinone analogs

Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds and pharmaceutical formulations thereof are also provided.

Compounds useful as hypoglycemic agents and for treating Alzheimer's

Provided is a method for treating hyperglycemia utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant method are novel and, accordingly, such compounds and pharmaceutical formulations thereof, are also provided.

Hypoglycemic agents

The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake of serotonin and norepinephrine.

Serotonin and norepinephrine uptake inhibitors

7-(Thienothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.

Thienothienylglycyl cephalosporin derivatives

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Carmel, IN, United States of America

David C Hunden