Rempex Pharmaceuticals, Inc.

Horizon Orphan LLC

Melinta Subsidiary Corp.

Mpex Pharmaceuticals, Inc.

Other

Raptor Pharmaceuticals Inc.

Melinta Therapeutics, Inc.

David C Griffith

Michael N Dudley

Olga Rodny

Scott J Hecker

Serge H Boyer

Mark William Surber

Olga Lomovskaya

Keith A Bostian

Gavin C Hirst

Raja K Reddy

Maxim Totrov

Jeffery S Loutit

Elizabeth E Morgan

Ruslan Y Tsivkovski

Tomasz W Glinka

Neil Berkley

Gopal Krishna

Jeffrey S Loutit

Karen Fusaro

Serge Henri Boyer

Jefferey S Loutit

Adel Rafai Far

Dario Lehoux

Serge Boyer

Mike Dudley

Methods of treating or ameliorating urinary tract infection (UTI), including complicated urinary tract infection (cUTI) and acute pyelonephritis (AP), comprising administering a composition comprising a cyclic boronic acid ester vaborbactam in combination with meropenem are disclosed herewith.

Methods of treating bacterial infections

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives

Compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility, are disclosed. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.

Tetracycline compositions

The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.

The present invention relates to methods and compositions for the treatment of pulmonary inflammation. In particular, methods and compositions using aerosol levofloxacin or ofloxacin to reduce pulmonary inflammation are provided.

Topical use of levofloxacin for reducing lung inflammation

Method of treating or ameliorating a bacterial infection comprising administering a composition comprising a cyclic boronic acid ester compound in combination with a carbapenem antibacterial agent such as Biapenem, and the pharmacokinetics studies thereof are provided.

Cyclic boronic acid ester derivatives and therapeutic uses thereof

Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.

Aerosolized fluoroquinolones and uses thereof

Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising

Use of aerosolized levofloxacin for treating cystic fibrosis

The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to the use of aerosolized fluoroquinolones formulated with divalent or trivalent cations and having improved pulmonary availability for the treatment and management of bacterial infections of the lung and upper respiratory tract.

Aerosol fluoroquinolone formulations for improved pharmacokinetics

Growing community of inventors

San Marcos, CA, United States of America

David C Griffith