Usbiomaterials Corporation

Other

Novabone Products, LLC

University System of Maryland

Schott Ag

University of Florida Research Foundation, Incorporated

Osteobiologics, Inc.

Univ. of Maryland Baltimore

David C Greenspan

Leonard J Litkowski

Gary David Hack

Jon Kenneth West

Sean Lee

Gregory J Pomrink

Jipin Zhong

Joshua Clark

Zehra Tosun

Paul D Thut

Srinivas Katta

Kristine M Kieswetter

Neil C Leatherbury

Gabriele G Niederauer

James L Meyers

Susanna Kessler

Oliver Forberich

Claire Buchwar

Larry L Hench

Barbara Dale Boyan

Guy LaTorre

Cecilia Cao

Cecilia A Gao

Mason Diamond

Dennis McBride

Marlo Tan Walpole

Richard Davis

Alice D Greenspan

Cecilia A Cao

Jon K West

The present invention relates to combination products including bioactive glass and collagen as well as kits comprising the same.

Combination products including bioactive glass and collagen and kits including the same

This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.

Devices and methods for the regeneration of bony defects

Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for regenerating bone comprising collagen and bioactive glass are provided.

System and kit for delivering collagen bioglass composite bone grafting materials for regenerating hard tissues

Compositions including crosslinked collagen and bioactive glass having an average pore size of at least 100 microns and methods of preparation thereof.

Ionically crosslinked materials and methods for production

The present invention involves new cosmetic, personal care, cleaning agent, biocidal agent, functional food, and nutritional supplement compositions. These new compositions incorporate bioactive glass into cosmetics, personal care items, cleaning agents, biocidal agents, functional foods, and nutritional supplements. The present invention also involves methods of making and methods of using such compositions.

Cosmetic, personal care, cleaning agent, and nutritional supplement compositions and methods of making and using same

Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.

Anti-inflammatory and antimicrobial uses for bioactive glass compositions

Compositions and methods for systemically minimizing the inflammatory effects of TNF-&agr; are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20 &mgr;m, alone or in combination with anti-inflammatory agents and other therapeutic agents. The compositions can include an appropriate carrier for oral, intramuscular, intraperitoneal or intravenous administration. When administered to a patient, the particles bring about elevated levels of IL-6 and do not cause elevated levels of TNF-&agr;.

Anti-inflammatory bioactive glass particulates

Compositions and methods for treating nails and adjacent tissues are disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with therapeutic agents, hydrophilic polymers, and other optional components. The compositions optionally include an appropriate aqueous carrier for topical administration. The methods involve applying an effective nail-enhancing amount of the composition to the nails and adjacent tissues for a sufficient amount of time to cause the formation of a hydroxyapatite or other calcium phosphate mineral layer on the nail surface.

Compositions and methods for treating nails and adjacent tissues

This invention relates, generally, to nutritional supplements which contain bioactive glass. These supplements are useful in both veterinary and human contexts. The compositions of the subject invention can be used to achieve a number of advantageous results including: enhancing the growth rates of young animals, osteogenic stimulation, strengthening the skeletal structure, and treating osteoporosis.

Nutritional supplements formulated from bioactive materials

A method for treating wounds including contacting a wound with an effective wound healing amount of bioactive glass and topical antibiotic and composition for the accelerated healing of wounds and burns including particulates of bioactive glass and at least one topical antibiotic.

Composition and method for acceleration of wound and burn healing

Methods for whitening teeth including contacting teeth with an effective amount of particulate bioactive glass are disclosed.

Methods and compositions for whitening teeth

Biodegradable polymeric therapeutic substantially nonporous implant materials incorporating bioactive ceramics such as Bioglass&reg; ceramic are provided. These implants provide increased mechanical properties and pH control, enabling the use of these materials to design porous and nonporous therapeutic implants used as cell scaffolds for healing of tissue defects or fixation devices, having desired degradation times, mechanical properties, elasticity and biocompatibility.

Biodegradable implant material comprising bioactive ceramic

A novel silica based bioactive glass composition that can be used in conjunction with a delivery agent such as a toothpaste, gel saliva, etc. having a particle size range <90 &mgr;m which will form a rapid and continuous reaction with body fluids due to the immediate and long term ionic release of Ca and P from the core silica particles, to produce a stable crystalline hydroxy carbonate apatite layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity.

Growing community of inventors

Gainesville, FL, United States of America

David C Greenspan