Ford Global Technolgoies, LLC

Massachusetts Institute of Technology

David C Freeman

Alexander H Slocum, Jr

Daniel M Kabat

Angela N Koehler

Nicholas B Struntz

Shelby Doyle

Andre Richters

Provided herein are compounds useful for modulating the activity of an androgen receptor, or a variant thereof, and related compositions and methods. Compounds of the invention are useful for antagonizing the androgen receptor splice variant AR-v7, and for the treatment of castration-resistant prostate cancer.

Small molecule modulators of the androgen receptor

A flow control valve, comprising a flow controlling valve configured to deflect from a generally planar posture to an increasingly nonplanar posture responsive to a relative increase in pressure difference and flow across the valve element; and a support element including a support structure supporting the valve element in its undeflected state; at least a first contact surface recessed from the support structure and configured to engage the valve element only when the valve element is deflected; and a flow passage wherein an effective flow-through volume through the at least one opening and the flow passage decreases as deflection of the valve element increases.

Variable stiffness flow control valve

A flow control valve is provided. According to one aspect of this disclosure, the flow control valve includes a valve element and a support element. The valve element is configured to deflect responsive to a change in pressure difference across the valve element. The support element cooperates with the valve element to present an effective flow-through area that changes as the valve element deflects. The amount of relative engagement between the valve element and the support element changes as the valve element deflects. External vibration causes the valve element to vibrate to reduce stiction or ice buildup.

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Watertown, MA, United States of America

David C Freeman